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At the time of writing, the exact cause of IBS is not known. There are, however, numerous factors that seem likely to play a role in its development. These include: Diet - Diet is thought to be a prime culprit in the development of IBS. Diet, of course, can have a major influence on the gut microbiome which plays a key role in digestive health. This is one reason our IBS nutritionists often recommend a dietary response to IBS. Nervous system abnormalities - Nerves within the digestive systems of some people may overreact when the gut is stretched because of gas or overeating.