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When planning for the Lares trek to Machu Picchu, you should arrive in Cusco at least two days before you trek to acclimatize. Its highest point is 4650 meters above sea level, and this can cause altitude sickness especially if you are new to the area. Travelers are advised to arrive a few days earlier before the trek for them to adapt to the high altitude. Permits are not required for the trek, meaning that you can arrive in Cusco and be on the trail in a day or two depending on the season.
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