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2-Chlorotrityl chloride resin is a highly adaptable resin used for the solid-phase immobilization of various chemical functionalities, including:
Carboxylic acids
Alcohols & Phenols
Amines, Imidazoles, and Hydroxylamines
Cleavage Methods
The functional groups immobilized on 2-Chlorotrityl chloride resin can be efficiently released using:
1-50% TFA in DCM (with 5% TIS for enhanced stability)
AcOH/TFE/DCM solution (for selective cleavage of carboxylic acids)
0.5% TFA in DCM or HFIP in DCM
Applications
Peptide Synthesis – Ideal for solid-phase peptide assembly.
Organic Chemistry – Widely used in the synthesis of protein mimics and complex molecules.
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