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Androgenetic alopecia (AGA), commonly referred to as male or female pattern hair loss, is the most prevalent form of hair loss worldwide. It is characterized by progressive miniaturization of hair follicles influenced by genetic predisposition and androgen sensitivity, particularly to dihydrotestosterone (DHT). This condition typically follows a patterned distribution, which varies between men and women.
Current treatments for androgenetic alopecia primarily include FDA-approved medications such as minoxidil and finasteride. Minoxidil, a topical vasodilator, is used to prolong the anagen (growth) phase of the hair cycle, while finasteride is an oral 5-alpha-reductase inhibitor that lowers DHT levels, slowing follicular miniaturization. Both treatments require long-term commitment and often yield moderate to significant results in halting hair loss progression.
In recent years, emerging therapies have broadened the landscape of androgenetic alopecia management. Platelet-rich plasma (PRP) therapy has gained popularity for its ability to stimulate follicular activity using autologous growth factors. Low-level laser therapy (LLLT), which uses red light to enhance cellular activity in the scalp, has shown promise in both male and female AGA cases. Microneedling, often used in combination with topical agents, enhances transdermal absorption and triggers wound-healing responses that may support hair regrowth.
Telogen effluvium, a condition marked by diffuse hair shedding often caused by stress, illness, or hormonal changes, can coexist with androgenetic alopecia, complicating diagnosis and treatment. Differentiating between the two is essential, as telogen effluvium is usually reversible once the trigger is addressed, whereas androgenetic alopecia typically progresses without intervention.
In addition to pharmacological and procedural treatments, there is growing interest in nutraceuticals, stem cell therapy, exosome-based treatments, and gene-editing technologies. These advancements hold promise for more targeted and personalized therapies in the future.
For individuals seeking a clinically guided approach to hair restoration, Dermis Oracle offers specialized diagnostics and evidence-based treatment plans tailored to manage androgenetic alopecia and its related conditions effectively.
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