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Chronic Fatigue Syndrome (ME/CFS) is more than just feeling tired—it's a complex neurological and immune disorder marked by overwhelming fatigue that persists even after ample rest. At its core lies post-exertional malaise (PEM): a dramatic worsening of symptoms following minimal physical or mental activity .PEM is often delayed—beginning 12 to 48 hours after exertion—and recovery can take days or even weeks
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