Bilastine: Uses, Interactions, Mechanism Of Action

Bilastine is a second-generation antihistamine which was developed in recent times and is primarily prescribed to relieve the symptoms of allergic conditions. Since its approval in the European Union and other countries, it has gained fame in terms of effectiveness and safety. To make it work in the body, the effects it may produce, and how to use it as a medicine, you must learn how it works in the body.

MECHANISM OF ACTION
Bilastine functions as a selective, competitive antagonist of the histamine H1 receptor:
Histamine Blockade: Allergens cause immune cells called mast cells to release histamine during an allergy response. Following this, histamine attaches to H1 receptors that are found all over the body, mostly in the blood vessels, skin, eyes, nose, and lungs. This bonding together causes the usual allergy signs and symptoms, like itching, coughing, and redness and swelling due to dilation and increased arterial permeability.
Selective Antagonism: Bilastine operates by attaching itself to these H1 receptors to a greater degree. By occupying the receptor sites, it literally stops histamine from connecting. This stops the receptor from being triggered, which stops the allergic symptoms that follow. Because it is very selective for the H1 receptor, it doesn't bind to other receptors like muscarinic, serotonin, or adrenergic receptors very well. This is why it doesn't cause many of the side effects that are common with first-generation antihistamines, like drowsiness, sedation, or dry mouth.
Studies also show that bilastine may stop the release of other pro-inflammatory cytokines and binding molecules from human mast cells and basophils. This could have an anti-allergic effect that goes beyond just blocking receptors.